Welcome to the Brown Lab at West Virginia University School of Medicine!
We are members of of the Department of Neurobiology and Anatomy, Centers for Neuroscience, and Center for Basic and Translational Stroke Research.
The Brown laboratory studies how sex differences influence brain inflammatory responses to acute systemic inflammation. Current studies address how brain microvascular endothelial cells integrate systemic and CNS inflammatory responses to maintain cerebral homeostasis. We combine animal models of sepsis and ischemic stroke with in vitro brain endothelial cell models to address our research questions.
Our research will identify the short-term and long-term repercussions of acute systemic inflammatory conditions, including sepsis and stroke, on brain function, as well as uncover some of the sex-specific factors that contribute to neurological dysfunction and disease.